Italian side, Spezia, is the destination for the Englishman.
A loan with an option to buy for €15million is almost agreed between both clubs.
Contracts are being exchanged between both club sides ahead of the move.
Medical tests have been scheduled for early next week.
Spezia have long identified Ampadu as a candidate for their defensive positions.
The fact that he has played in Italy, haven spent last season with Venezia, made things smoother.